Multivariate methods in pharmaceutical applications

Simultaneous spectrophotometric determination of lidocaine and hydrocortisone acetate in pharmaceutical preparations by multivariate calibration methods

The multivariate calibration method, partial least square regression (PLS) was applied for thesimultaneous spectrophotometric determination of Lidocaine (LID) and Hydrocortisone acetate(HCA) in their mixtures. The parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good a...

Pharmaceutical Applications of Insilico methods : A Review

Conventionally, drugs were discovered by synthesizing compounds in a time-consuming multi-step processes against a battery of in vivo biological screens and further investigating the promising candidates for their pharmacokinetic properties, metabolism and potential toxicity. Sophisticated insilico approaches has given a tremendous opportunity to pharmaceutical companies to identify new potenti...

Multivariate image processing: methods and applications

Sparse machine learning methods with applications in multivariate signal processing

This thesis details theoretical and empirical work that draws from two main subject areas: Machine Learning (ML) and Digital Signal Processing (DSP). A unified general framework is given for the application of sparse machine learning methods to multivariate signal processing. In particular, methods that enforce sparsity will be employed for reasons of computational efficiency, regularisation, a...

simultaneous spectrophotometric determination of lidocaine and hydrocortisone acetate in pharmaceutical preparations by multivariate calibration methods

the multivariate calibration method, partial least square regression (pls) was applied for thesimultaneous spectrophotometric determination of lidocaine (lid) and hydrocortisone acetate(hca) in their mixtures. the parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good a...